Development of a Membrane Liquid-Based Thin-Layer Cell Film Maker

Abstract

Specimen production is a key step in cytological diagnosis. This paper proposes a membrane liquid-based thin-layer cell film maker based on the principle of liquid-based thin-layer cell production. To be specific, the designed maker mainly consists of two parts including the mechanical system and control system. For the mechanical part, a novel type of polar coordinate manipulator is developed with the corresponding working scheme. In order to handle cell breakage and collection, a dynamic sealing head system is designed, which saves cost and improves automation. For the control part, both hardware and software are designed to realize the functions including the motion feedback and control of mechanical components, the measurement and adjustment of the pressure system, and the real-time information interaction between human and machine interface. Experimental results demonstrate that the developed maker is capable of fully meeting the requirements of clinical pathology, clinical detection and diagnosis, owing to the advantages such as the compact structure, high cost performance, stable performance and high satisfaction rate.

Keywords

• liquid based thin-layer cell preparation
• microporous filtration membrane
• film machine
• dynamic seal
• pressure control system