Synthesis, Characterization, and Antibacterial Activity of Ni(II), Pd(II), and Pt(II) Complexes with 2-benzoylthiobenzimidazole

Abstract

The thioester compound of 2-benzoylthiobenzimidazole was prepared by S-acylation of 2-mercaptobenzimidazole with benzoyl chloride and reactions of divalent Ni, Pd, and Pt salts with one equivalent of thioester compound a new complexes were isolated in a high percentage. A tetradentate thioester compound and a bivalent metal complexes were identified by CHNS analysis, IR, magnetic susceptibility, molar conductivity, UV-Vis, and 1H, 13C NMR spectroscopies. The anti-bacterial activity of the thioester compound and the bivalent metal complexes were studied using disk diffusion test method against the bacterial species, Staphylococcus aureus, and Pseudomonas aeruginosa. The divalent metal complexes demonstrated a greater activities compared to thioester compound a lone. Structural analysis showed that 2-benzoylthiobenzimidazole L behaves as a neutral four coordination modes compound and bonds to the bivalent metals cation through two nitrogen, sulfur and oxygen atoms. Our study informed the formation of four-coordinate square planar complexes structure around divalent metal salts of Ni, Pd, and Pt.

Keywords

• 2-benzoylthiobenzimidazole; Square planar geometry; Divalent metal ions complexes; Antibacterial activity, Structural study.