Risk Factors for Left Ventricular Hypertrophy in Patients with Diabetic Kidney Disease: A Multi-Center Study

Abstract

Xiangdong Wang,1,* Dongpo Zhu,2,* Leilei Peng,1 Yan Gao,3 Xiaodong Li4 1Department of Blood Purification, Baoding People’s Hospital, Baoding, 071030, People’s Republic of China; 2Department of Internal Medicine, Baoding People’s Hospital, Baoding, 071030, People’s Republic of China; 3Department of Nephrology, Affiliated Hospital of Hebei University, Baoding, 071030, People’s Republic of China; 4Department of Nephrology, Baoding No. 1 Central Hospital of Hebei Medical University, Baoding, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaodong Li, Department of Nephrology, Baoding No. 1 Central Hospital of Hebei Medical University, Baoding, Hebei, 071000, People’s Republic of China, Email [email protected]: One of the earliest echocardiographic features of the left ventricle explored extensively was left ventricular hypertrophy (LVH). Numerous studies have identified a few risk factors for LVH, however, there are few for people with diabetic kidney disease (DKD). Therefore, we evaluated the risk factors in DKD patients with LVH by analyzing laboratory data and clinical traits.Methods: In total, 500 DKD patients in the Baoding area from February 2016 and June 2020 were admitted and classified as an experimental group (240 cases, LVH group) and a control group (260 cases, non-LVH group). The clinical parameters and laboratory tests of the participants were collected and analyzed retrospectively.Results: Compared with the control group, low-density lipoprotein (LDL), body mass index (BMI), intact parathyroid hormone (iPTH), systolic blood pressure, and 24-hour urine protein were higher in the experimental group (all P< 0.01). Multivariable logistic regression analysis results confirmed that high BMI (OR=1.332, 95% CI 1.016– 1.537, P=0.006), LDL (OR=1.279, 95% CI 1.008– 1.369, P=0.014) and 24-hour urine proteins (OR=1.446, 95% CI 1.104– 1.643, P=0.016) were statistically significant. The ROC analysis illustrated that the optimum cutoff value of BMI, LDL, and 24-hour urine proteins for diagnosis of LVH in patients with DKD was 27.36 kg/m2, 4.18 mmol/L, and 1.42 g respectively.Conclusion: The increase in BMI, LDL, and 24-hour urine proteins quantification are independent risk factors for LVH in patients with DKD.Keywords: diabetic kidney disease, chronic kidney disease, risk factors, left ventricular hypertrophy

Keywords

• diabetic kidney disease
• chronic kidney disease
• risk factors
• left ventricular hypertrophy