Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

Roxanne Oshidari; Jonathan Strecker; Daniel K. C. Chung; Karan J. Abraham; Janet N. Y. Chan; Christopher J. Damaren; Karim Mekhail

doi:10.1038/s41467-018-05009-7

Nature Communications (Jul 2018)

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

Roxanne Oshidari,
Jonathan Strecker,
Daniel K. C. Chung,
Karan J. Abraham,
Janet N. Y. Chan,
Christopher J. Damaren,
Karim Mekhail

Affiliations

Roxanne Oshidari: Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto
Jonathan Strecker: Department of Molecular Genetics, MaRS Centre, University of Toronto
Daniel K. C. Chung: Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto
Karan J. Abraham: Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto
Janet N. Y. Chan: Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto
Christopher J. Damaren: Institute for Aerospace Studies, University of Toronto
Karim Mekhail: Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto

DOI: https://doi.org/10.1038/s41467-018-05009-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Following DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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