A Polyphenols-Rich Extract from <i>Moricandia sinaica</i> Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo

Sahar El-mekkawy; Abdelaaty A. Shahat; Ali S. Alqahtani; Mansour S. Alsaid; Mohamed A.O. Abdelfattah; Riaz Ullah; Mahmoud Emam; Abdelaziz Yasri; Mansour Sobeh

doi:10.3390/molecules25215049

Molecules (Oct 2020)

A Polyphenols-Rich Extract from <i>Moricandia sinaica</i> Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo

Sahar El-mekkawy,
Abdelaaty A. Shahat,
Ali S. Alqahtani,
Mansour S. Alsaid,
Mohamed A.O. Abdelfattah,
Riaz Ullah,
Mahmoud Emam,
Abdelaziz Yasri,
Mansour Sobeh

Affiliations

Sahar El-mekkawy: Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Giza 12622, Egypt
Abdelaaty A. Shahat: Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Ali S. Alqahtani: Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mansour S. Alsaid: Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mohamed A.O. Abdelfattah: College of Engineering and Technology, American University of the Middle East, Kuwait
Riaz Ullah: Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mahmoud Emam: College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Abdelaziz Yasri: AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660–Hay MoulayRachid, 43150 Ben-Guerir, Morocco
Mansour Sobeh: AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660–Hay MoulayRachid, 43150 Ben-Guerir, Morocco

DOI: https://doi.org/10.3390/molecules25215049
Journal volume & issue: Vol. 25, no. 21
p. 5049

Abstract

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In this study, the aerial parts of Moricandia sinaica were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test and the tail flick method. The anti-inflammatory and the antipyretic activities were evaluated using carrageenan-induced paw edema in rats and brewer’s yeast-induced pyrexia in mice, respectively. The aqueous fraction of the methanol extract (MS-3) showed to be the most bioactive among the other investigated fractions. At the dose of 500 mg/kg, the fraction (MS-3) showed a significant percentage inhibition of the carrageenan-induced edema by 52.4% (p p p M. sinaica exerts potential analgesic, anti-inflammatory and antipyretic effects in rats.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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