A Polyphenols-Rich Extract from <i>Moricandia sinaica</i> Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo
Sahar El-mekkawy,
Abdelaaty A. Shahat,
Ali S. Alqahtani,
Mansour S. Alsaid,
Mohamed A.O. Abdelfattah,
Riaz Ullah,
Mahmoud Emam,
Abdelaziz Yasri,
Mansour Sobeh
Affiliations
Sahar El-mekkawy
Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Giza 12622, Egypt
Abdelaaty A. Shahat
Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Ali S. Alqahtani
Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mansour S. Alsaid
Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mohamed A.O. Abdelfattah
College of Engineering and Technology, American University of the Middle East, Kuwait
Riaz Ullah
Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia
Mahmoud Emam
College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Abdelaziz Yasri
AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660–Hay MoulayRachid, 43150 Ben-Guerir, Morocco
Mansour Sobeh
AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660–Hay MoulayRachid, 43150 Ben-Guerir, Morocco
In this study, the aerial parts of Moricandia sinaica were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test and the tail flick method. The anti-inflammatory and the antipyretic activities were evaluated using carrageenan-induced paw edema in rats and brewer’s yeast-induced pyrexia in mice, respectively. The aqueous fraction of the methanol extract (MS-3) showed to be the most bioactive among the other investigated fractions. At the dose of 500 mg/kg, the fraction (MS-3) showed a significant percentage inhibition of the carrageenan-induced edema by 52.4% (p p p M. sinaica exerts potential analgesic, anti-inflammatory and antipyretic effects in rats.
