Cellular Physiology and Biochemistry (Feb 2016)

Expression of 58-kD Microspherule Protein (MSP58) is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients

  • Wei Lin,
  • Shu-hui Dai,
  • Tao Chen,
  • Nobuyuki Kawai,
  • Keisuke Miyake,
  • Masaki Okada,
  • Reiji Haba,
  • Yuka Yamamoto,
  • Takashi Tamiya,
  • Zhou Fei

DOI
https://doi.org/10.1159/000438656
Journal volume & issue
Vol. 38, no. 2
pp. 635 – 645

Abstract

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Background/Aims: The nucleolar 58-kDa microspherule protein (MSP58) has important transcriptional regulation functions and plays a crucial role in the tumorigenesis and progression of cancers. 3'-deoxy-3'-[18F]fluorothymidine (FLT) has emerged as a promising positron emission tomography (PET) tracer for evaluating tumor malignancy and cell proliferation. Methods: In the present study, the expression of MSP58 was evaluated by immunohistochemistry and the corresponding PET image was examined using FLT-PET in 55 patients with various grades of gliomas. Results: The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P r = 0.61, P r = 0.59, P Conclusion: These results indicate that MSP58 plays an important role in cell proliferation and will be one of the potential candidates of molecular therapy targeting proliferation. FLT-PET might be used as an early measure of treatment response in the proliferation-targeted therapy.

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