Antimicrobial Activities, Characterization and Synthesis of Organotin(IV) Complexes with Benzohydrazide Derivative

Abstract

An efficient and facile method for the synthesis of 2-hydroxy-N’-{(E)-[6'-(2H-1",2",3"-triazol-2"-yl)pyridin-3'-yl]methylidene}benzohydrazide via N-arylation is described. The synthesized ligand was further coordinated with a variety of organotin(IV) salts. Structural elucidations of ligand and the complexes thus formed were made by CHN, IR, NMR and MS. The newly synthesized compounds were also screened for antifungal, antibacterial, cytotoxic and antiurease activities. The compounds 3,7,9 showed best antifungal activity against various strains while diorganotin(IV) moieties (7,8,10) showed excellent antibacterial activities. Compound 3 and 9 remained good antiurease and cytotoxic agents.

Keywords

• n-arylation
• organotin(iv)
• 1
• 2
• 3-triazol
• 2-hydroxybenzohydrazide