Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation

Simona Sestito; Sara Chiarugi; Eleonora Margheritis; Massimiliano Runfola; Simone Bertini; Gianpiero Garau; Simona Rapposelli

doi:10.3390/proceedings2019022045

Proceedings (Aug 2019)

Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation

Simona Sestito,
Sara Chiarugi,
Eleonora Margheritis,
Massimiliano Runfola,
Simone Bertini,
Gianpiero Garau,
Simona Rapposelli

Affiliations

Simona Sestito: Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Sara Chiarugi: BioStructures Lab, CNI@NEST—Istituto Italiano di Tecnologia, 56126 Pisa, Italy
Eleonora Margheritis: BioStructures Lab, CNI@NEST—Istituto Italiano di Tecnologia, 56126 Pisa, Italy
Massimiliano Runfola: Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Simone Bertini: Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Gianpiero Garau: BioStructures Lab, CNI@NEST—Istituto Italiano di Tecnologia, 56126 Pisa, Italy
Simona Rapposelli: Department of Pharmacy, University of Pisa, 56126 Pisa, Italy

DOI: https://doi.org/10.3390/proceedings2019022045
Journal volume & issue: Vol. 22, no. 1
p. 45

Abstract

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The struggle to find novel efficacious pharmacological approaches for cancer treatment has ledto the identification of several kinases involved in neoplastic genesis and cell development. [...]

Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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