Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

Krishna Samanta; Gary R. Mirams; Anant B. Parekh

doi:10.1038/s41467-017-02638-2

Nature Communications (Jan 2018)

Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

Krishna Samanta,
Gary R. Mirams,
Anant B. Parekh

Affiliations

Krishna Samanta: Department of Physiology, Anatomy and Genetics, Oxford University
Gary R. Mirams: Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, Nottingham University
Anant B. Parekh: Department of Physiology, Anatomy and Genetics, Oxford University

DOI: https://doi.org/10.1038/s41467-017-02638-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Mitochondrial Ca2+ homoeostasis is tightly regulated and export of Ca2+ is mediated by an Na+Ca2+ exchanger. Here authors show that in depolarised mitochondria the exchanger initially operates in reverse mode, transporting cytosolic Ca2+ into the matrix before it reverts to its forward mode state.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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