Composite dietary antioxidant index was negatively associated with the prevalence of diabetes independent of cardiovascular diseases

Abstract

Abstract Aim The association between composite dietary antioxidant index (CDAI) and diabetes remains unknown. Our study was to investigate the association of CDAI with diabetes. Methods A total of 11,956 participants were enrolled from the National Health and Nutrition Examination Surveys (NHANES). The CDAI was calculated from the intake of six dietary antioxidants. Multivariable logistic regressions were performed to explore the associations between CDAI and the prevalence of diabetes and glycemic index. Non-linear associations were explored using restricted cubic splines. Results In the multivariate logistic regression model, the odds ratio (95% confidence interval) of CDAI associating with obesity was 0.98 (0.97-1.00; p = 0.033). Compared with the lowest quartile, the highest quartile was related to 0.84-fold risk of diabetes (0.71–0.99; p = 0.035). However, CDAI was not independently associated with fasting glucose and hemoglobin A1c. Conclusion CDAI was negatively associated with diabetes and the relationship was independent of other traditional risk factors.

Keywords

• Composite dietary antioxidant index
• Diabetes
• Antioxidant
• NHANES
• Cross-sectional study