Skin Rash as the First Manifestation of Pediatric Chronic Neutrophilic Leukemia
ZHOU Yabin,
DUAN Ruoyu,
YAO Jiafeng,
QIN Maoquan,
DENG Jianghong,
XU Zigang,
WU Runhui
Affiliations
ZHOU Yabin
Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
DUAN Ruoyu
Department 2 of Hemotology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
YAO Jiafeng
Department 2 of Hemotology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
QIN Maoquan
Department of Stem Cell Transplantation, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
DENG Jianghong
Department of Rheumatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
XU Zigang
Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
WU Runhui
Department 2 of Hemotology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
A 6-year-old girl presented with recurrent skin rash at the initial stage, recent joint pain, and neutrophilia was found during a routine blood test. After a multidisciplinary case discussion, she was diagnosed with chronic neutrophil leukemia, and the symptoms were relieved after hydroxyurea and luxolitinib treatment. She received the allogeneic hematopoietic stem cell transplantation subsequently. At present, she is in stable condition and under follow-up. Chronic neutrophil leukemia is a rare disease, which rarely occurs in children. It is more difficult to diagnose in patients with skin rash as the first manifestation. The diagnosis and treatment of this case reflects the important role of multidisciplinary cooperation in the diagnosis and treatment of difficult and rare diseases.
