Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

Solène Clavreul; Lamiae Abdeladim; Edwin Hernández-Garzón; Dragos Niculescu; Jason Durand; Sio-Hoï Ieng; Raphaëlle Barry; Gilles Bonvento; Emmanuel Beaurepaire; Jean Livet; Karine Loulier

doi:10.1038/s41467-019-12791-5

Nature Communications (Oct 2019)

Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

Solène Clavreul,
Lamiae Abdeladim,
Edwin Hernández-Garzón,
Dragos Niculescu,
Jason Durand,
Sio-Hoï Ieng,
Raphaëlle Barry,
Gilles Bonvento,
Emmanuel Beaurepaire,
Jean Livet,
Karine Loulier

Affiliations

Solène Clavreul: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Lamiae Abdeladim: Laboratory for Optics and Biosciences, Ecole polytechnique, CNRS, INSERM, IP Paris
Edwin Hernández-Garzón: Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Département de la Recherche Fondamentale, Institut de biologie François Jacob, Molecular Imaging Research Center (MIRCen), CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay
Dragos Niculescu: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Jason Durand: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Sio-Hoï Ieng: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Raphaëlle Barry: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Gilles Bonvento: Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Département de la Recherche Fondamentale, Institut de biologie François Jacob, Molecular Imaging Research Center (MIRCen), CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay
Emmanuel Beaurepaire: Laboratory for Optics and Biosciences, Ecole polytechnique, CNRS, INSERM, IP Paris
Jean Livet: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Karine Loulier: Sorbonne Université, INSERM, CNRS, Institut de la Vision

DOI: https://doi.org/10.1038/s41467-019-12791-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astrocytes organize in a non-stereotyped manner and that cortical astrocyte subtypes are not intrinsically specified.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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