Involvement of epithelia-derived exosomes in chronic respiratory diseases

Yu Yang; Lin Yuan; Xizi Du; Kai Zhou; Ling Qin; Leyuan Wang; Ming Yang; Mengping Wu; Zhiyuan Zheng; Yang Xiang; Xiangping Qu; Huijun Liu; Xiaoqun Qin; Chi Liu

Biomedicine & Pharmacotherapy (Nov 2021)

Involvement of epithelia-derived exosomes in chronic respiratory diseases

Yu Yang,
Lin Yuan,
Xizi Du,
Kai Zhou,
Ling Qin,
Leyuan Wang,
Ming Yang,
Mengping Wu,
Zhiyuan Zheng,
Yang Xiang,
Xiangping Qu,
Huijun Liu,
Xiaoqun Qin,
Chi Liu

Affiliations

Yu Yang: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China
Lin Yuan: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xizi Du: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Kai Zhou: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Ling Qin: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China
Leyuan Wang: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Ming Yang: Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
Mengping Wu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Zhiyuan Zheng: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Basic and Clinical Research Laboratory of Major Respiratory Diseases, Central South University, Changsha, Hunan, China
Yang Xiang: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xiangping Qu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Huijun Liu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xiaoqun Qin: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Chi Liu: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Research Center of China-Africa Infectious Diseases, Xiangya School of Medicine Central South University, Changsha, Hunan, China; Corresponding author at: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Journal volume & issue: Vol. 143
p. 112189

Abstract

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Exosomes are tiny membrane lipid bilayer vesicles (φ40–100 nm) formed by the fusion of multivesicular bodies with plasma membrane, which are released extracellular by exocytosis. As natural nanocarriers, exosomes contain a variety of signal substances of the mother cell: nucleic acids, proteins and lipids, etc., which always play a vital role in the transmission of signal molecules between different cells. Epithelial cells are the first-line defense system against various inhaled allergens causing chronic respiratory diseases (CRD), such as asthma and chronic obstructive pulmonary disease (COPD). It’s noted that increasing literature shows the exosomes derived from epithelial cells are involved in the pathogenesis of CRD. Moreover, the correlations between exosome cargo and the disease phenotypes show a high potential of using exosomes as biomarkers of CRD. In this review, we mainly focus on the physiological functions of epithelial-derived exosomes and illustrate the involved mechanism of epithelial-derived exosomes in common CRD.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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