mSphere (Aug 2021)
Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment
- Liang Chen,
- Michael C. Zody,
- Clara Di Germanio,
- Rachel Martinelli,
- Jose R. Mediavilla,
- Marcus H. Cunningham,
- Kaelea Composto,
- Kar Fai Chow,
- Milena Kordalewska,
- André Corvelo,
- Dayna M. Oschwald,
- Samantha Fennessey,
- Marygrace Zetkulic,
- Sophia Dar,
- Yael Kramer,
- Barun Mathema,
- Soren Germer,
- Mars Stone,
- Graham Simmons,
- Michael P. Busch,
- Tom Maniatis,
- David S. Perlin,
- Barry N. Kreiswirth
Affiliations
- Liang Chen
- ORCiD
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- Michael C. Zody
- New York Genome Center, New York, New York, USA
- Clara Di Germanio
- Vitalant Research Institute, San Francisco, California, USA
- Rachel Martinelli
- Vitalant Research Institute, San Francisco, California, USA
- Jose R. Mediavilla
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- Marcus H. Cunningham
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- Kaelea Composto
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- Kar Fai Chow
- Hackensack Medical University Center, Hackensack, New Jersey, USA
- Milena Kordalewska
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- André Corvelo
- New York Genome Center, New York, New York, USA
- Dayna M. Oschwald
- New York Genome Center, New York, New York, USA
- Samantha Fennessey
- New York Genome Center, New York, New York, USA
- Marygrace Zetkulic
- Hackensack Medical University Center, Hackensack, New Jersey, USA
- Sophia Dar
- Hackensack Medical University Center, Hackensack, New Jersey, USA
- Yael Kramer
- Hackensack Medical University Center, Hackensack, New Jersey, USA
- Barun Mathema
- Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York, USA
- Soren Germer
- New York Genome Center, New York, New York, USA
- Mars Stone
- Vitalant Research Institute, San Francisco, California, USA
- Graham Simmons
- Vitalant Research Institute, San Francisco, California, USA
- Michael P. Busch
- Vitalant Research Institute, San Francisco, California, USA
- Tom Maniatis
- New York Genome Center, New York, New York, USA
- David S. Perlin
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- Barry N. Kreiswirth
- ORCiD
- Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA
- DOI
- https://doi.org/10.1128/mSphere.00480-21
- Journal volume & issue
-
Vol. 6,
no. 4
Abstract
Over a year of the COVID-19 pandemic, distinct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have arisen in multiple geographic areas around the world. SARS-CoV-2 variants of concern (VOCs), i.e., B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.2 (delta), harboring mutations and/or deletions in spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) regions showed evidence of increased transmissibility and disease severity and possible reduced vaccine efficacy.
