Fluorodeoxyglucose-positron emission tomography as a potential alternative tool for functional diagnosis of glycogen storage disease type I

Takeshi Sato, MD; Mikako Inokuchi, MD, PhD; Satsuki Nakano, MD; Yu Iwabuchi, MD, PhD; Tetsu Hayashida, MD, PhD; Tomohiro Ishii, MD, PhD; Tomonobu Hasegawa, MD, PhD

Radiology Case Reports (Jan 2023)

Fluorodeoxyglucose-positron emission tomography as a potential alternative tool for functional diagnosis of glycogen storage disease type I

Takeshi Sato, MD,
Mikako Inokuchi, MD, PhD,
Satsuki Nakano, MD,
Yu Iwabuchi, MD, PhD,
Tetsu Hayashida, MD, PhD,
Tomohiro Ishii, MD, PhD,
Tomonobu Hasegawa, MD, PhD

Affiliations

Takeshi Sato, MD: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Mikako Inokuchi, MD, PhD: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Satsuki Nakano, MD: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Yu Iwabuchi, MD, PhD: Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Tetsu Hayashida, MD, PhD: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Tomohiro Ishii, MD, PhD: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Tomonobu Hasegawa, MD, PhD: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Corresponding author.

Journal volume & issue: Vol. 18, no. 1
pp. 91 – 93

Abstract

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A 43-year-old woman with genetically confirmed glycogen storage disease type Ib was suspected to have left breast cancer. Fluorodeoxyglucose-positron emission tomography showed high fluorodeoxyglucose accumulation in the whole liver as well as left mammary gland. We consider that high fluorodeoxyglucose accumulation in the liver of patients with glycogen storage disease type I is caused by impaired glucose-6-phosphate metabolism due to the congenital deficiency of glucose-6-phosphatase activities in hepatocytes. This study describes fluorodeoxyglucose-positron emission tomography as a potential alternative tool to diagnose glycogen storage disease type I functionally.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: http://www.journals.elsevier.com/radiology-case-reports/

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