Научно-практическая ревматология (Dec 2013)

IgG4-RELATED DISEASE. CLINICAL NOTES

  • Vladimir Ivanovich Vasilyev,
  • O A Logvinenko,
  • S Kh Sedyshev,
  • S G Radenska-Lopovok,
  • E B Rodionova,
  • E N Aleksandrova,
  • N A Probatova,
  • N V Kokosadze,
  • T N Safonova,
  • E L Nasonov

DOI
https://doi.org/10.14412/1995-4484-2013-1552
Journal volume & issue
Vol. 51, no. 5
pp. 578 – 585

Abstract

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IgG4-related diseases are a new nosological entity that encompasses a few previously known diseases. IgG4-related systemic disease is diagnosed if two or more affected organs are detected. This group of diseases has two similar signs: serological (elevated serum IgG4 subclass concentrations) and histological (organ and tissue infiltration from plasmo-cytes secreting IgG4, and eosinophils, and the development of fibrosclerosis and phlebitis obliterans). The paper describes two cases. In one case, a multisystemic disease was observed virtually at its onset whereas in the other this lesion was diagnosed several years after the natural course of the disease.

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