Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix

Yuichi Matsushima; Kazuya Takahashi; Song Yue; Yuki Fujiyoshi; Hideaki Yoshioka; Masamune Aihara; Daiki Setoyama; Takeshi Uchiumi; Satoshi Fukuchi; Dongchon Kang

doi:10.1038/s42003-021-02498-z

Communications Biology (Aug 2021)

Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix

Yuichi Matsushima,
Kazuya Takahashi,
Song Yue,
Yuki Fujiyoshi,
Hideaki Yoshioka,
Masamune Aihara,
Daiki Setoyama,
Takeshi Uchiumi,
Satoshi Fukuchi,
Dongchon Kang

Affiliations

Yuichi Matsushima: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Kazuya Takahashi: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Song Yue: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Yuki Fujiyoshi: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Hideaki Yoshioka: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Masamune Aihara: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Daiki Setoyama: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Takeshi Uchiumi: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Satoshi Fukuchi: Department of Life Science and Informatics, Maebashi Institute of Technology
Dongchon Kang: Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku

DOI: https://doi.org/10.1038/s42003-021-02498-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Yuichi Matsushima et al. revealed that Human ATP-dependent Lon protease (LONP1), a mitochondrial protease with unfolding activity, serves as a gatekeeper for several mitochondrial matrix entering proteins: supporting the folding of required proteins and degrading the aberrant ones.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal