Brain and Behavior (Apr 2024)

Periodontal disease and risk of Alzheimer's disease: A two‐sample Mendelian randomization

  • Conglei Hu,
  • Hui Li,
  • Liping Huang,
  • Rui Wang,
  • Zeyu Wang,
  • Rui Ma,
  • Bei Chang,
  • Shiting Li,
  • Hongcai Li,
  • Guangwen Li

DOI
https://doi.org/10.1002/brb3.3486
Journal volume & issue
Vol. 14, no. 4
pp. n/a – n/a

Abstract

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Abstract Background Evidence from observational studies and clinical trials suggests an association between periodontal disease and Alzheimer's disease (AD). However, the causal relationship between periodontal disease and AD remains to be determined. Methods We obtained periodontal disease data from the FinnGen database and two sets of AD data from the IEU consortium and PGC databases. Subsequently, we conducted a two‐sample Mendelian randomization (MR) analysis to investigate the causal relationship between periodontal disease and AD. Results The results of the random‐effects IVW analysis revealed no evidence of a genetic causal relationship between periodontal disease and AD, regardless of whether the AD data from the IEU consortium or the AD data from the PGC database were utilized. No heterogeneity, multiple effects of levels, or outliers were observed in this study. Conclusions Our findings indicate that there is no causal relationship between periodontal disease and AD at the genetic level.

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