烟雾血管病与免疫相关疾病 Moyamoya Angiopathy and Immune-Related Diseases

Abstract

烟雾血管病是一类病因不明的颅内大动脉闭塞性疾病，主要表现为颈内动脉系统慢性狭窄、闭塞和异常血管网的形成。临床和流行病学研究发现，烟雾血管病患者具有较高的免疫相关疾病患病率，提示免疫因素在烟雾血管病的发生、发展中扮演了重要角色。本文旨在对烟雾血管病与感染、血管炎及自身免疫性疾病等免疫相关疾病的相关性研究展开综述，探讨免疫相关疾病参与烟雾血管病发病的潜在机制。 Abstract: Moyamoya angiopathy (MMA) is an intracranial large artery occlusive disease of unknown etiology, characterized by chronic stenosis/occlusion of the internal carotid artery system and the formation of abnormal vascular networks. Clinical and epidemiological studies have demonstrated that patients with MMA have a higher prevalence of immune-related diseases, suggesting that immune factors play an important role in the occurrence and progression of MMA. This paper aims to review the correlation between MMA and immune-related diseases such as infections, vasculitis, and autoimmune diseases, and explore the potential mechanisms of immune-related diseases involved in the pathogenesis of MMA.

Keywords

• 烟雾血管病
• 感染
• 炎症
• 自身免疫性疾病
• moyamoya angiopathy
• infection
• inflammation
• autoimmune disease