MOLECULAR BIOLOGICAL CHARACTERISTICS OF ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA

E. V. Chernyshova; D. S. Abramov; D. M. Konovalov; S. S. Larin; N. V. Myakova

doi:10.17650/1818-8346-2016-11-4-25-31

Онкогематология (Jan 2017)

MOLECULAR BIOLOGICAL CHARACTERISTICS OF ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA

E. V. Chernyshova,
D. S. Abramov,
D. M. Konovalov,
S. S. Larin,
N. V. Myakova

Affiliations

E. V. Chernyshova: Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev
D. S. Abramov: Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev
D. M. Konovalov: Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev
S. S. Larin: Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev
N. V. Myakova: Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev

DOI: https://doi.org/10.17650/1818-8346-2016-11-4-25-31
Journal volume & issue: Vol. 11, no. 4
pp. 25 – 31

Abstract

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ALK-positive anaplastic large cell lymphoma is a heterogeneous group of mature T-cell non-Hodgkin lymphoma, and is characterized by CD30/Ki-1 expression. Recently, value of various prognostic factors is investigated. These include clinical, histological and molecular genetic changes associated with different signaling pathways activation. Some features of the mechanism of action of anaplastic lymphoma kinases and targeted therapies possibilities addressed in this review.

Published in Онкогематология

ISSN: 1818-8346 (Print); 2413-4023 (Online)
Publisher: ABV-press
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://oncohematology.abvpress.ru/

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Abstract

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