Immune Checkpoint Inhibitor-Associated Myocarditis

Grigorios Chatzantonis, MD; Georg Evers, MD; Claudia Meier, MD; Michael Bietenbeck, PhD; Anca Florian, MD; Karin Klingel, MD; Annalen Bleckmann, MD; Ali Yilmaz, MD

JACC: Case Reports (Apr 2020)

Immune Checkpoint Inhibitor-Associated Myocarditis

Grigorios Chatzantonis, MD,
Georg Evers, MD,
Claudia Meier, MD,
Michael Bietenbeck, PhD,
Anca Florian, MD,
Karin Klingel, MD,
Annalen Bleckmann, MD,
Ali Yilmaz, MD

Affiliations

Grigorios Chatzantonis, MD: Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany
Georg Evers, MD: Department of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Münster, Münster, Germany
Claudia Meier, MD: Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany
Michael Bietenbeck, PhD: Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany
Anca Florian, MD: Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany
Karin Klingel, MD: Division of Cardiopathology, Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany
Annalen Bleckmann, MD: Department of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Münster, Münster, Germany
Ali Yilmaz, MD: Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany; Address for correspondence: Dr. Ali Yilmaz, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany.

Journal volume & issue: Vol. 2, no. 4
pp. 630 – 635

Abstract

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Immune checkpoint inhibitors (ICIs) can induce immunity-related adverse events. We demonstrate the clinical use of cardiac magnetic resonance and endomyocardial biopsy in the diagnosis and subsequent monitoring of ICI-associated myocarditis, suggesting the need to establish and evaluate a cardiac monitoring protocol for patients under ICI therapy. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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