Tissue-resident memory T cells play a key role in the efficacy of cancer vaccines

Abstract

Resident memory CD8+T cells (TRM) usually defined by the CD103 marker represent a new subset of long-lived memory T cells that remain in the tissues. We directly demonstrate their specific role in cancer vaccine-induced tumor regression. In human, they also seem to play a major role in tumor immunosurveillance.

Keywords

• resident memory t cell
• cancer vaccine
• tumor microenvironment
• route of immunization
• immunosurveillance