Rapid Development of Targeting circRNAs in Cardiovascular Diseases

Chao Zhang; Si Tong Huo; Zhiyong Wu; Lina Chen; Chang Wen; Honghao Chen; William W. Du; Nan Wu; Daogang Guan; Sen Lian; Burton B. Yang

Molecular Therapy: Nucleic Acids (Sep 2020)

Rapid Development of Targeting circRNAs in Cardiovascular Diseases

Chao Zhang,
Si Tong Huo,
Zhiyong Wu,
Lina Chen,
Chang Wen,
Honghao Chen,
William W. Du,
Nan Wu,
Daogang Guan,
Sen Lian,
Burton B. Yang

Affiliations

Chao Zhang: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Corresponding author: Chao Zhang, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 705, Life Science Building, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China.
Si Tong Huo: Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada
Zhiyong Wu: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510000, Guangdong Province, China
Lina Chen: Basic Medical College, Xiangnan University, Chenzhou 523000, China
Chang Wen: Jiangxi Medical College, Nanchang University, Nanchang 330000, Nanchang, Jiangxi Province, China
Honghao Chen: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China
William W. Du: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada
Nan Wu: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada
Daogang Guan: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China
Sen Lian: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Corresponding author: Sen Lian, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China.
Burton B. Yang: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Corresponding author: Burton B. Yang, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, S110, S-Wing Research Building, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.

Journal volume & issue: Vol. 21
pp. 568 – 576

Abstract

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Circular RNAs (circRNAs) are circularized, single-stranded RNAs that are covalently linked. With their abundance in tissues and developmental stage-specific expression, circRNAs participate in a variety of physiological and pathological processes. In this review, we discuss the development of circRNAs used as biomarkers and therapeutic targets for cardiovascular diseases (CVDs), focusing on recent discoveries and applications of exosomal circRNAs that highlight opportunities and challenges. Some studies have identified a spectrum of circRNAs that are differentially expressed in CVDs, while other studies further manipulated specific circRNA expression and showed an ameliorated pathogenic state such as ischemic injury, hypertrophy, and cardiac fibrosis. Studies and applications of circRNAs are being rapidly developed. We expect to see clinical use of circRNAs as biomarkers and targets for disease treatment in the near future.

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

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