The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements
Jean-Sébastien Paquette,
Caroline Rhéaume,
Pierre Cordeau,
Julie-Alexandra Moulin,
Etienne Audet-Walsh,
Virginie Blanchette,
Jean-Philippe Drouin-Chartier,
Alfred-Kodjo Toi,
Angelo Tremblay
Affiliations
Jean-Sébastien Paquette
Primary Care Research and Innovation Laboratory (Laboratoire ARIMED), Groupe de Médecine de Famille Universitaire du Nord de Lanaudière, Centre Intégré de Santé et de Services Sociaux de Lanaudière, Joliette, QC J6E 5X7, Canada
Caroline Rhéaume
Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Laval University, Québec City, QC G1V 0A6, Canada
Pierre Cordeau
Vitam, Research Center on Sustainable Health, Université Laval, Québec City, QC G1V 0A6, Canada
Julie-Alexandra Moulin
Vitam, Research Center on Sustainable Health, Université Laval, Québec City, QC G1V 0A6, Canada
Etienne Audet-Walsh
Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada
Virginie Blanchette
Vitam, Research Center on Sustainable Health, Université Laval, Québec City, QC G1V 0A6, Canada
Jean-Philippe Drouin-Chartier
NUTRISS (Nutrition, Health and Society) Research Centre, Institute on Nutrition and Functional Foods (INAF), Laval University, Québec City, QC G1V 0A6, Canada
Alfred-Kodjo Toi
Vitam, Research Center on Sustainable Health, Université Laval, Québec City, QC G1V 0A6, Canada
Angelo Tremblay
NUTRISS (Nutrition, Health and Society) Research Centre, Institute on Nutrition and Functional Foods (INAF), Laval University, Québec City, QC G1V 0A6, Canada
Aging is not a disease; it is a natural evolution of human physiology. Medical advances have extended our life expectancy, but chronic diseases and geriatric syndrome continue to affect the increasingly aging population. Yet modern medicine perpetuates an approach based on treatment rather than prevention and education. In order to help solve this ever-growing problem, a new discipline has emerged: lifestyle medicine. Nutrition, physical activity, stress management, restorative sleep, social connection, and avoidance of risky substances are the pillars on which lifestyle medicine is founded. The aim of this discipline is to increase healthspan and reduce the duration of morbidity by making changes to our lifestyle. In this review, we propose the use of klotho protein as a novel biomarker for lifestyle medicine in order to quantify and monitor the health status of individuals, as no integrative tool currently exists.
