Hematology, Transfusion and Cell Therapy (Nov 2021)

A RARE ASSOCIATION IN A CASE WITH HEREDITARY SPHEROCYTOSIS: SPECTRIN BETA (SPTB) AND JAK-2 MUTATION

  • Fatma YILMAZ,
  • Murat ALBAYRAK,
  • Merih REİS ARAS,
  • Senem MARAL,
  • Hacer Berna AFACAN ÖZTÜRK,
  • Pınar TIĞLIOĞLU,
  • Mesut TIĞLIOĞLU,
  • Buğra SAĞLAM

Journal volume & issue
Vol. 43
p. S51

Abstract

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Case report: Five types of gene variants are seen in hereditary spherocytosis (ANK, SPTB, SPTA1, SLC4A1, EPB42). JAK2 V617F mutation; is most common seen in bcr-abl negative chronic myeloproliferative diseases. As a result of NGS performed before splenectomy, SPTB c.4973+2T> C and JAK-2 c.1849G>T p.(Val617Phe) mutations were detected. Co-occurrence of these two mutations requires special attention in terms of the management of thrombocytosis and side effects that may occur after splenectomy.