Nature Communications (Oct 2020)

Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids

  • Brooke Schuster,
  • Michael Junkin,
  • Sara Saheb Kashaf,
  • Isabel Romero-Calvo,
  • Kori Kirby,
  • Jonathan Matthews,
  • Christopher R. Weber,
  • Andrey Rzhetsky,
  • Kevin P. White,
  • Savaş Tay

DOI
https://doi.org/10.1038/s41467-020-19058-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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The use of organoids in personalized medicine is promising but high throughput platforms are needed. Here the authors develop an automated, high-throughput, microfluidic 3D organoid culture system that allows combinatorial and dynamic drug treatments and real-time analysis of organoids.