Nature Communications (Jun 2021)
Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
- Kosuke Miyauchi,
- Yu Adachi,
- Keisuke Tonouchi,
- Taiki Yajima,
- Yasuyo Harada,
- Hidehiro Fukuyama,
- Senka Deno,
- Yoichiro Iwakura,
- Akihiko Yoshimura,
- Hideki Hasegawa,
- Katsuyuki Yugi,
- Shin-ichiro Fujii,
- Osamu Ohara,
- Yoshimasa Takahashi,
- Masato Kubo
Affiliations
- Kosuke Miyauchi
- Laboratory for Cytokine Regulation, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Yu Adachi
- Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
- Keisuke Tonouchi
- Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
- Taiki Yajima
- Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science
- Yasuyo Harada
- Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science
- Hidehiro Fukuyama
- Laboratory for Lymphocyte Differentiation, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Senka Deno
- Laboratory for Integrated Cellular Systems, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Yoichiro Iwakura
- Center for Animal Disease Models, Research Institute for Biomedical Science, Tokyo University of Science
- Akihiko Yoshimura
- Department of Microbiology and Immunology, Keio University School of Medicine
- Hideki Hasegawa
- Influenza Virus Research Center, National Institute of Infectious Diseases
- Katsuyuki Yugi
- Laboratory for Integrated Cellular Systems, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Shin-ichiro Fujii
- Laboratory for Immunotherapy, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Osamu Ohara
- Laboratory for Integrative Genomics, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- Yoshimasa Takahashi
- Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
- Masato Kubo
- Laboratory for Cytokine Regulation, Research Center for Integrative Medical Sciences (IMS), RIKEN Yokohama Institute
- DOI
- https://doi.org/10.1038/s41467-021-24090-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.
