Identification and antimicrobial resistance of pathogens in neonatal septicemia in China—A meta-analysis

Abstract

Objectives: The purpose of this study was to analyze the distribution and antimicrobial resistance of common bacterial pathogens causing neonatal septicemia based on a systematic review of published studies in China. Methods: Articles on neonatal sepsis published in the Chinese literature from 2009 to 2014 were identified according to the inclusion and exclusion criteria. Data were extracted and analyzed using Comprehensive Meta-Analysis software. Results: A total of 71 studies were included, in which a total of 8080 bacterial species were isolated from culture-positive blood samples. The pooled distribution rates of common bacterial pathogens were as follows: Staphylococcus 67.1% (95% confidence interval (CI) 63.3–70.6%), Enterococcus 4.1% (95% CI 3.5–4.8%), Streptococcus 2.3% (95% CI 1.6–3.2%), Escherichia coli 7.4% (95% CI 6.4–8.7%), Klebsiella 6.5% (95% CI 5.2–8.2%), Enterobacterium 2.3% (95% CI 1.9–2.8%), Acinetobacter 1.6% (95% CI 1.3–2.0%), Pseudomonas 1.7% (95% CI 1.3–2.2%). Among the Staphylococcus aureus strains isolated, more than 60% were methicillin-resistant (MRSA). In addition, over 50% of the Gram-negative isolates, including Escherichia and Klebsiella, were resistant to the commonly used third-generation cephalosporins. Most of the Gram-positive and Gram-negative bacteria isolated were sensitive to aminoglycosides, especially amikacin. Conclusions: It is concluded that Staphylococcus, especially coagulase-negative Staphylococcus, continues to be the principal organism responsible for neonatal septicemia in China; Enterobacteriaceae are common among the Gram-negative isolates. Significant numbers of MRSA and multidrug-resistant Gram-negative bacteria are being isolated as pathogens responsible for neonatal septicemia in China.

Keywords

• Septicemia
• Infants
• Newborn
• Pathogens
• Antimicrobial resistance