Nature Communications (May 2021)
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
- Andrea de la Fuente-Alonso,
- Marta Toral,
- Alvaro Alfayate,
- María Jesús Ruiz-Rodríguez,
- Elena Bonzón-Kulichenko,
- Gisela Teixido-Tura,
- Sara Martínez-Martínez,
- María José Méndez-Olivares,
- Dolores López-Maderuelo,
- Ileana González-Valdés,
- Eusebio Garcia-Izquierdo,
- Susana Mingo,
- Carlos E. Martín,
- Laura Muiño-Mosquera,
- Julie De Backer,
- J. Francisco Nistal,
- Alberto Forteza,
- Arturo Evangelista,
- Jesús Vázquez,
- Miguel R. Campanero,
- Juan Miguel Redondo
Affiliations
- Andrea de la Fuente-Alonso
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Marta Toral
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Alvaro Alfayate
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- María Jesús Ruiz-Rodríguez
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Elena Bonzón-Kulichenko
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Gisela Teixido-Tura
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Sara Martínez-Martínez
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- María José Méndez-Olivares
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Dolores López-Maderuelo
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Ileana González-Valdés
- Cardiovascular Proteomics Laboratoy, CNIC
- Eusebio Garcia-Izquierdo
- Cardiology Department, Hospital Universitario Puerta de Hierro
- Susana Mingo
- Cardiology Department, Hospital Universitario Puerta de Hierro
- Carlos E. Martín
- Cardiac Surgery Department, Hospital Universitario Puerta de Hierro
- Laura Muiño-Mosquera
- Center for Medical Genetics Ghent, Ghent University Hospital
- Julie De Backer
- Center for Medical Genetics Ghent, Ghent University Hospital
- J. Francisco Nistal
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Alberto Forteza
- Cardiac Surgery Department, Hospital Universitario Puerta de Hierro
- Arturo Evangelista
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Jesús Vázquez
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Miguel R. Campanero
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
- Juan Miguel Redondo
- Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- DOI
- https://doi.org/10.1038/s41467-021-22933-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent protein kinase reverts MFS aortopathy in mice.
