Isoniazid metabolism and hepatotoxicity

Pengcheng Wang; Komal Pradhan; Xiao-bo Zhong; Xiaochao Ma

doi:10.1016/j.apsb.2016.07.014

Acta Pharmaceutica Sinica B (Sep 2016)

Isoniazid metabolism and hepatotoxicity

Pengcheng Wang,
Komal Pradhan,
Xiao-bo Zhong,
Xiaochao Ma

Affiliations

Pengcheng Wang: Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
Komal Pradhan: Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
Xiao-bo Zhong: Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA
Xiaochao Ma: Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA

DOI: https://doi.org/10.1016/j.apsb.2016.07.014
Journal volume & issue: Vol. 6, no. 5
pp. 384 – 392

Abstract

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Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b

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