Nutrients (Apr 2023)
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
- Giulia Collatuzzo,
- Eva Negri,
- Claudio Pelucchi,
- Rossella Bonzi,
- Federica Turati,
- Charles S. Rabkin,
- Linda M. Liao,
- Rashmi Sinha,
- Domenico Palli,
- Monica Ferraroni,
- Lizbeth López-Carrillo,
- Nuno Lunet,
- Samantha Morais,
- Demetrius Albanes,
- Stephanie J. Weinstein,
- Dominick Parisi,
- David Zaridze,
- Dmitry Maximovitch,
- Trinidad Dierssen-Sotos,
- José Juan Jiménez-Moleón,
- Jesus Vioque,
- Manoli Garcia de la Hera,
- Maria Paula Curado,
- Emmanuel Dias-Neto,
- Raúl Ulises Hernández-Ramírez,
- Malaquias López-Cervantes,
- Mary H. Ward,
- Shoichiro Tsugane,
- Akihisa Hidaka,
- Areti Lagiou,
- Pagona Lagiou,
- Zuo-Feng Zhang,
- Antonia Trichopoulou,
- Anna Karakatsani,
- Maria Constanza Camargo,
- Carlo La Vecchia,
- Paolo Boffetta
Affiliations
- Giulia Collatuzzo
- Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
- Eva Negri
- Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
- Claudio Pelucchi
- Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
- Rossella Bonzi
- Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
- Federica Turati
- Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
- Charles S. Rabkin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Linda M. Liao
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Rashmi Sinha
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Domenico Palli
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, 50139 Florence, Italy
- Monica Ferraroni
- Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
- Lizbeth López-Carrillo
- Mexico National Institute of Public Health, Cuernavaca 62100, Mexico
- Nuno Lunet
- EPIUnit—Instituto de Saúde Pública da Universidade do Porto, 4050-600 Porto, Portugal
- Samantha Morais
- EPIUnit—Instituto de Saúde Pública da Universidade do Porto, 4050-600 Porto, Portugal
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Stephanie J. Weinstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Dominick Parisi
- Information management Services, Inc., Silver Spring, MD 20904, USA
- David Zaridze
- Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia
- Dmitry Maximovitch
- Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia
- Trinidad Dierssen-Sotos
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- José Juan Jiménez-Moleón
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Jesus Vioque
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Manoli Garcia de la Hera
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
- Maria Paula Curado
- Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo 01508-010, Brazil
- Emmanuel Dias-Neto
- Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo 01508-010, Brazil
- Raúl Ulises Hernández-Ramírez
- Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA
- Malaquias López-Cervantes
- Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Coyoacán 04510, Mexico
- Mary H. Ward
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Shoichiro Tsugane
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan
- Akihisa Hidaka
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan
- Areti Lagiou
- Department of Public and Community Health, School of Public Health, University of West Attica, 11521 Athens, Greece
- Pagona Lagiou
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
- Zuo-Feng Zhang
- Department of Epidemiology, UCLA Fielding School of Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, CA 10833, USA
- Antonia Trichopoulou
- Hellenic Health Foundation, 11527 Athens, Greece
- Anna Karakatsani
- Hellenic Health Foundation, 11527 Athens, Greece
- Maria Constanza Camargo
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA
- Carlo La Vecchia
- Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
- Paolo Boffetta
- Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
- DOI
- https://doi.org/10.3390/nu15081877
- Journal volume & issue
-
Vol. 15,
no. 8
p. 1877
Abstract
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
Keywords
