Correlations and Prognostic Values of Antiendotoxin Immunity in Children with Different Stages of Septic Process during Treatment

Abstract

There were researched 91 children with gram-negative sepsis. All patients have been selected by a random way into 2 groups. The first group included children received pathogenetic immune correction with donors’ plasma enriched with the antibodies to endotoxin; the second group consisted of children who got complex treatment only. The different stages of gram-negative sepsis lead to acute deviation of antiendotoxin immune deficiency which manifested with immune deficiency of specific anti-ET-IgG and ascending primary (low-affinity) anti-ET-IgM under excessive activation of non-specific components LBP and sCD14. Surgical treatment with adequate sanitation of purulent focus in the affected organ, based on prognostic criteria developed and immunomodulation led to a rapid regression of clinical signs of disease and made possible to increase a clinical efficacy of the therapy.

Keywords

• endotoxin, immunity, gram-negative sepsis, immunocorrection