mBio
(Jun 2021)
<i>In Vitro</i>
Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
Melina Vallbracht,
Henriette Lötzsch,
Barbara G. Klupp,
Walter Fuchs,
Benjamin Vollmer,
Kay Grünewald,
Marija Backovic,
Felix A. Rey,
Thomas C. Mettenleiter
Affiliations
Melina Vallbracht
ORCiD Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Henriette Lötzsch
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Barbara G. Klupp
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Walter Fuchs
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Benjamin Vollmer
Centre for Structural Systems Biology, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Hamburg, Germany
Kay Grünewald
Centre for Structural Systems Biology, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Hamburg, Germany
Marija Backovic
Institut Pasteur, Structural Virology Unit, Department of Virology, CNRS UMR3569, Paris, France
Felix A. Rey
Institut Pasteur, Structural Virology Unit, Department of Virology, CNRS UMR3569, Paris, France
Thomas C. Mettenleiter
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
DOI
https://doi.org/10.1128/mBio.00557-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.
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