The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anaesthesia

Abstract

The effects of vitamin C administration at varying time intervals on rectal temperature, respiratory rates, heart rates and sleeping time following xylazine anaesthesia was evaluated in rabbits. A total of 36 rabbits placed in six groups(A-F) with 6 animals per group each were used. Groups A and B were used as controls for vitamin C (120 mg/kg, oral) and xylazine (4 mg/kg, intramuscular) treatments, respectively, while groups C-F received vitamin C at four intervals prior to xylazine anaesthesia. The result of the study showed that vitamin Cpre-medication prior to xylazine anaesthesia induced depression in respiratory and heart rates and a slight increase in rectal temperature. It also significantly increased sleeping time in rabbits (p0.05) in temperature between groups either before or after xylazine administration. It was concluded that vitamin C alters the clinical parameters as well as the sleeping time in rabbits under xylazine anaesthesia.

Keywords

• Anaesthesia
• Physiology
• Rabbit
• Vitamin C
• Xylazine.