Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance

Aiyan Ji; Hongyue Lou; Chunrong Qu; Wanglong Lu; Yifan Hao; Jiafeng Li; Yuyang Wu; Tonghang Chang; Hao Chen; Zhen Cheng

doi:10.1038/s41467-022-31521-y

Nature Communications (Jul 2022)

Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance

Aiyan Ji,
Hongyue Lou,
Chunrong Qu,
Wanglong Lu,
Yifan Hao,
Jiafeng Li,
Yuyang Wu,
Tonghang Chang,
Hao Chen,
Zhen Cheng

Affiliations

Aiyan Ji: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hongyue Lou: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Chunrong Qu: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Wanglong Lu: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yifan Hao: Shanghai Institute of Technical Physics of the Chinese Academy of Sciences
Jiafeng Li: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yuyang Wu: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Tonghang Chang: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hao Chen: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Zhen Cheng: State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-31521-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Small molecule NIR-II fluorophores are of interest for a range of applications but can suffer from chemical and photostability issues. Here, the authors report on the development of an acceptor molecule with improved stability in alkaline conditions expanding the range of possible applications.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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