Association of Chronic HBV Infection with Chronic Lymphoproliferative Disorders: A Review and Case Report

Abstract

This article presents a clinical report on the associated course of chronic hepatitis B virus (HBV) infection with Castleman's disease (CD). We noticed the reactivation of previously latent chronic hepatitis B (CHB) with high replicative activity of HBV DNA during the treatment of lymphoproliferative disease. This clinical case dictates the need for pre-emptive therapy of HBV infection with nucleoside analogues in patients who are receiving chemotherapy.

Keywords

• chronic hepatitis B;
• Castleman's disease;
• chemotherapy;
• rituximab;
• reactivation of viral infextion