Communications Biology (Mar 2021)

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

  • Cristina Olivieri,
  • Caitlin Walker,
  • Adak Karamafrooz,
  • Yingjie Wang,
  • V. S. Manu,
  • Fernando Porcelli,
  • Donald K. Blumenthal,
  • David D. Thomas,
  • David A. Bernlohr,
  • Simon M. Sandford,
  • Susan S. Taylor,
  • Gianluigi Veglia

DOI
https://doi.org/10.1038/s42003-021-01819-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric cooperativity may contribute to the pathology that PKA-CDNAJB1 drives.