Nature Communications (Oct 2018)

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

  • Erol S. Kavvas,
  • Edward Catoiu,
  • Nathan Mih,
  • James T. Yurkovich,
  • Yara Seif,
  • Nicholas Dillon,
  • David Heckmann,
  • Amitesh Anand,
  • Laurence Yang,
  • Victor Nizet,
  • Jonathan M. Monk,
  • Bernhard O. Palsson

DOI
https://doi.org/10.1038/s41467-018-06634-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Mycobacterium tuberculosis exhibits complex evolution of antimicrobial resistance (AMR). Here, the authors perform machine learning and structural analysis to identify signatures of AMR evolution to 13 antibiotics.