Advanced Ultrasound in Diagnosis and Therapy (Dec 2023)

The Value of CEUS in the Diagnosis and Treatment of Thyroid Primary Squamous Cell Carcinoma: A Case Report

  • Yiming Li, BM, Jing Xiao, MD, Fang Xie, MD, Yu Lin, BM, Mingbo Zhang, MD, Yukun Luo, MD

DOI
https://doi.org/10.37015/AUDT.2023.220027
Journal volume & issue
Vol. 7, no. 4
pp. 412 – 415

Abstract

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Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare clinical disease characterized by rapid growth, high invasiveness, and a poor prognosis. A 66-year-old male patient was admitted due to throat pain and dysphagia. Ultrasound revealed a calcified hypoechoic mass in the right lobe of the thyroid gland, measuring approximately 35.3 ml. Ultrasound and PET-CT both indicated high suspicion of malignancy. The patient underwent contrast-enhanced US-guided biopsy, and the pathological results revealed poorly differentiated squamous cell carcinoma. CEUS was performed regularly during the Chemotherapy combined with pembrolizumab (PD-1) treatment courses. The vital area was significantly reduced with neither recurrence nor cervical lymph node metastasis. Surgical resection and chemotherapy combined with immunotherapy had a significant treatment effect in this case. CEUS is helpful for diagnosis confirmation, biopsy guidance and efficacy evaluation and has important clinical application value.

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