Prevalence Of Uropathogens In Diabetic Patients And Their Antimicrobial Susceptibility Pattern

Abstract

Introduction: Diabetes mellitus has adverse effect on genitourinary system and patients suffering from diabetes mellitus are more prone to have urinary tract infection with risk of potentially harmful extension of infection to kidneys. Aim: The study was carried out to find the prevalence of uropathogens in diabetic patients and to study their antibiotic susceptibility pattern. Material and methods: Urine samples were collected from 270 diabetic patients (inpatients and outpatients) of our hospital. The specimens were processed and examined for the various uropathogens using the standard microbiological procedures. Antibiotic susceptibility testing was performed for various antibiotics by Kirby Bauer disc diffusion method and the results were interpreted as per CLSI guidelines. The data was tabulated and analyzed. Results: Uropathogens were isolated in 118 patients with females out numbering males (1.8:1). Escherichia coli was the most frequent isolate (41.5%), followed by Klebsiella species (14.4%), Proteus species (10.1%), Enterococci (8.4%), Pseudomonas aeruginosa (6.7%), Staphylococcus species (10.1%) and Candida albicans (8.4%). The isolates showed moderate to high level of resistance to various antibiotics tested. Conclusions: Continuous surveillance of antibiotic susceptibility patterns of uropathogens in diabetic patient should be done to ensure rational use of antibiotics for empirical and definitive treatment of urinary tract infections in this vulnerable group.

Keywords

• diabetes mellitus
• genitourinary
• uropathogens