Bagcilar Medical Bulletin (Dec 2023)

Plasma Fibrinogen to Albumin Ratio as an Indicator of Endothelial Dysfunction in Smoking

  • Şeyda Arslan,
  • Hilmi Furkan Arslan,
  • Zuhal Aydan Sağlam

DOI
https://doi.org/10.4274/BMB.galenos.2023.2023-08-077
Journal volume & issue
Vol. 8, no. 4
pp. 378 – 385

Abstract

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Objective: Smoking causes endothelial dysfunction by causing systemic inflammation. Our aim is to investigate the predictive role of fibrinogen albumin ratio (FAR), neutrophil lymphocyte ratio, platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR), monocyte high-density lipoprotein ratio (MHR), mean platelet volume (MPV), systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) which are the newest markers of systemic inflammation, in smoking. Method: The study was planned as a single-center, prospective case-control study. People aged between 20-45 years [n=76; female/male (n)=37/39] who met the inclusion criteria were included. Two groups consisting of smokers (n=38) and non-smokers (n=38) were compared according to demographic data and biochemical values. p-value was accepted as <0.05 in terms of statistical significance. Results: The proportion of men in the study group was 51.3% [total n=76; mean age 30.18±5.75 years; female/male (n):37/39]. There was no significant difference between the two groups of smokers (n=38) and non-smokers (n=38) in terms of gender and age (p=0.386, p=0.296, respectively). The average amount of smoking was 22.84±11.48 packs/year and 29.73±9.94 packs/day. FAR, MPV, MHR, MLR and SIRI were significantly higher and PLR was significantly lower in the smokers than the other group (p<0.05). According to the ROC analysis, the areas under the curve of FAR, MHR, MLR, SIRI, MPV and PLR were determined as 0.70, 0.90, 0.83, 0.80, 0.69 and 0.66, respectively (p<0.001). The variants with the highest sensitivity were monocytes and MPV, and the variant with the highest specificity was monocytes. FAR was positively correlated with MHR, MLR, SIRI (p=0.00, r=0.34; p=0.05, r=0.2; p=0.03, r=0.24, respectively). Conclusion: Our study suggests that new inflammatory markers can be used to predict the inflammatory process in endothelial dysfunction caused by smoking. It may be beneficial to conduct new studies with larger number of participants to see whether these markers can also be predictors of other silent inflammatory processes in non-smokers.

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