Coordination of metal center biogenesis in human cytochrome c oxidase

Eva Nývltová; Jonathan V. Dietz; Javier Seravalli; Oleh Khalimonchuk; Antoni Barrientos

doi:10.1038/s41467-022-31413-1

Nature Communications (Jun 2022)

Coordination of metal center biogenesis in human cytochrome c oxidase

Eva Nývltová,
Jonathan V. Dietz,
Javier Seravalli,
Oleh Khalimonchuk,
Antoni Barrientos

Affiliations

Eva Nývltová: Department of Neurology, University of Miami Miller School of Medicine
Jonathan V. Dietz: Department of Biochemistry, University of Nebraska-Lincoln
Javier Seravalli: Nebraska Redox Biology Center, University of Nebraska-Lincoln
Oleh Khalimonchuk: Department of Biochemistry, University of Nebraska-Lincoln
Antoni Barrientos: Department of Neurology, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1038/s41467-022-31413-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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