Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Yiren Wang; Yiren Wang; Shouying Chen; Shouying Chen; Shuilan Bao; Shuilan Bao; Li Yao; Li Yao; Zhongjian Wen; Zhongjian Wen; Lixia Xu; Xiaoman Chen; Shengmin Guo; Haowen Pang; Yun Zhou; Ping Zhou; Ping Zhou

doi:10.3389/fimmu.2024.1338922

Frontiers in Immunology (Feb 2024)

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Yiren Wang,
Yiren Wang,
Shouying Chen,
Shouying Chen,
Shuilan Bao,
Shuilan Bao,
Li Yao,
Li Yao,
Zhongjian Wen,
Zhongjian Wen,
Lixia Xu,
Xiaoman Chen,
Shengmin Guo,
Haowen Pang,
Yun Zhou,
Ping Zhou,
Ping Zhou

Affiliations

Yiren Wang: School of Nursing, Southwest Medical University, Luzhou, China
Yiren Wang: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Shouying Chen: School of Nursing, Southwest Medical University, Luzhou, China
Shouying Chen: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Shuilan Bao: School of Nursing, Southwest Medical University, Luzhou, China
Shuilan Bao: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Li Yao: School of Nursing, Southwest Medical University, Luzhou, China
Li Yao: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Zhongjian Wen: School of Nursing, Southwest Medical University, Luzhou, China
Zhongjian Wen: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Lixia Xu: School of Nursing, Southwest Medical University, Luzhou, China
Xiaoman Chen: School of Nursing, Southwest Medical University, Luzhou, China
Shengmin Guo: Department of Nursing, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Haowen Pang: Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Yun Zhou: School of Medical Information and Engineering, Southwest Medical University, Luzhou, China
Ping Zhou: Wound Healing Basic Research and Clinical Application Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Ping Zhou: Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

DOI: https://doi.org/10.3389/fimmu.2024.1338922
Journal volume & issue: Vol. 15

Abstract

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This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed the cellular and molecular responses of the skin to radiation, highlighting the role of myofibroblasts and the significant impact of Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The review delves into the epigenetic regulation of fibrotic gene expression, the contribution of extracellular matrix proteins to the fibrotic microenvironment, and the regulation of the immune system in the context of fibrosis. Additionally, it discusses the potential of biomaterials and artificial intelligence in medical research to advance the understanding and treatment of radiation-induced skin fibrosis, suggesting future directions involving bioinformatics and personalized therapeutic strategies to enhance patient quality of life.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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