41. The myocardial protective effect of dexmedetomidine in high risk patients undergoing aortic vascular surgery

Abstract

Dexmedetomidine provides perioperative cardiac protection in high risk patients assessment the effect of dexmedetomidine in high risk patients undergoing aortic vascular surgery. Arandomized study included 150 patients classified into two groups(n = 75). Group D: The patients received a loading dose of 1 μg/kg dexmedetomidine over 15 min before induction and maintained as an infusion of 0.3 μg/kg/hr to the end of the procedure. Group C: The patients received an equal volume of normalsaline. The dexmedetomidine decreased heart rate and minimized the changes in blood pressure compared to control group (p < 0.05). Also, it decreased the incidence of myocardial is chemia reflected by troponin I level and ECG changes(p < 0.05). Dexmedetomidine decreased the requirement for nitroglycerine and norepinephrine compared to control group (p < 0.05). The incidence of hypotension and bradycardia were significantly higher with dexmedetomidine (p < 0.05).The dexmedetomidine is safe and effective in patients undergoing aortic vascular surgery. It decreases the changes in heart rate and blood pressure during the procedures. It provide scardiac protection in high risk patients reflected by decreasing the incidence of myocardial ischemia and serum level of troponin. The main side effects of dexmedetomidine were hypotension and bradycardia.