Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate

Abstract

Cholesterol-3-3H,4-14C was injected intravenously in man and its transformation to cholestanol was studied. From the 3H:14C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-3H,4-14C the 3H:14C ratios in blood sterols remained unchanged for as long as 1 wk after the injection, which showed that cholestanol did not lose tritium by interconversion with cholestanone.

Keywords

• cholesterol-cholestanol conversion
• ketonic intermediate
• man
• cholesterol-3-3H,4-14C metabolism