Frontiers in Medicine (Feb 2022)
Changes in Serum Neutralizing Antibodies Levels During Convalescence of COVID-19 Patients
- Qing-Qing Chen,
- Qing-Qing Chen,
- Lei Gong,
- Lei Gong,
- Xiao-Min Wu,
- Xiao-Min Wu,
- Ya-Ting Feng,
- Ya-Ting Feng,
- Wan-Rong Luo,
- Wan-Rong Luo,
- Xue Zhou,
- Xue Zhou,
- Yuan Yuan,
- Yuan Yuan,
- Jun-Ling Yu,
- Jun-Ling Yu,
- Lan He,
- Lan He,
- Peng Wang,
- Peng Wang,
- Ying-Lu Ge,
- Ying-Lu Ge,
- Sai Hou,
- Sai Hou,
- Wei-Wei Li,
- Wei-Wei Li,
- Yong Sun,
- Yong Sun,
- Jia-Bing Wu,
- Jia-Bing Wu,
- Bin Su,
- Bin Su,
- Hai-Feng Pan,
- Hai-Feng Pan,
- Jun He,
- Jun He,
- Jun He,
- Zhi-Rong Liu,
- Zhi-Rong Liu
Affiliations
- Qing-Qing Chen
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Qing-Qing Chen
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Lei Gong
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Lei Gong
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Xiao-Min Wu
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Xiao-Min Wu
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Ya-Ting Feng
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
- Ya-Ting Feng
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Wan-Rong Luo
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Wan-Rong Luo
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Xue Zhou
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Xue Zhou
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Yuan Yuan
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Yuan Yuan
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Jun-Ling Yu
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Jun-Ling Yu
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Lan He
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Lan He
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Peng Wang
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Peng Wang
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Ying-Lu Ge
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Ying-Lu Ge
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Sai Hou
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Sai Hou
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Wei-Wei Li
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Wei-Wei Li
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Yong Sun
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Yong Sun
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Jia-Bing Wu
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Jia-Bing Wu
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Bin Su
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Bin Su
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Hai-Feng Pan
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
- Hai-Feng Pan
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Jun He
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Jun He
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- Jun He
- School of Public Health, Anhui Medical University, Hefei, China
- Zhi-Rong Liu
- Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China
- Zhi-Rong Liu
- Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China
- DOI
- https://doi.org/10.3389/fmed.2022.829273
- Journal volume & issue
-
Vol. 9
Abstract
Detection of serum-specific SARS-CoV-2 antibody has become a complementary means for the identification of coronavirus disease 2019 (COVID-19). As we already know, the neutralizing antibody titers in patients with COVID-19 decrease during the course of time after convalescence, whereas the duration of antibody responses in the convalescent patients has not been defined clearly. In the current study, we collected 148 serum samples from 37 confirmed COVID-19 cases with different disease severities. The neutralizing antibodies (Nabs), IgM and IgG against COVID-19 were determined by CLIA Microparticle and microneutralization assay, respectively. The time duration of serum titers of SARS-CoV-2 antibodies were recorded. Our results indicate that IgG (94.44%) and Nabs (89.19%) can be detected at low levels within 190–266 days of disease onset. The findings can advance knowledge regarding the antibody detection results for COVID-19 patients and provide a method for evaluating the immune response after vaccination.
Keywords
