(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis

Abstract

This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of each reaction type for which they have proved to be efficient catalytic species. Where relevant, a comparison is made with other organocatalysts in similar asymmetric reaction processes.

Keywords

• Asymmetric
• Organocatalysis
• Proline
• Synthesis
• Tetrazole