Инфекция и иммунитет (Jul 2014)

MULTIDRUG-RESISTANCE AND PRESENCE OF CLASS 1 INTEGRONS IN CLINICAL ISOLATES OF SALMONELLA ENTERICA SEROTYPE ENTERITIDIS, CIRCULATING IN ARMENIA

  • A. M. Sedrakyan,
  • K. A. Arakelova,
  • M. K. Zakaryan,
  • A. I. Hovhanisyan,
  • A. V. Asoyan,
  • Z. U. Gevorkyan,
  • A. A. Mnatsakanyan,
  • Z. A. Ktsoyan,
  • A. S. Boyajyan,
  • R. Aminov

DOI
https://doi.org/10.15789/2220-7619-2013-4-355-358
Journal volume & issue
Vol. 3, no. 4
pp. 355 – 358

Abstract

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Abstract. The aim of this work was detection of class 1 integrons and their contribution to the antimicrobial resistance phenotypes in strains of subspecies enterica serotype Enteritidis. S. Enteritidis strains (n = 29) were isolated from patients with salmonellosis at “Nork” Clinical Hospital of Infectious Diseases, Yerevan, Republic of Armenia. High prevalence of multi-drug resistance (MDR) phenotypes was revealed and isolates with MDR phenotypes which are rare in the S. Enteritidis serotype were observed. Class 1 integrons were detected in 27,6% of isolates, with the prevalence of a variable region of 1000 bp. Occurrence of the MDR phenotype was more frequent in integron-positive isolates compared to integron-negative isolates of S. Enteritidis. Further studies are necessary to reveal the genetic background of MDR phenotypes and to estimate the genetic kinship among the isolates. Our results suggest a rapid and large-scale penetration of antibiotic resistance genes into populations of S. Enteritidis, which complicates infection control. More rigorous regulations should be imposed on antibiotic use, together with a vigilant epidemiological surveillance, to prevent the emergence and spread of MDR S. Enteritidis.

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