A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes
Norman H.L. Chiu,
Jennifer H. Simpson,
Hongzhou Wang,
Bakhos A. Tannous
Affiliations
Norman H.L. Chiu
Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27402, United States; Joint School of Nanoscience and Nanoengineering, University of North Carolina Greensboro, Greensboro, NC 27401, United States; Corresponding author at: Chemistry and Biochemistry, University of North Carolina at Greensboro, 410 Patricia A. Sullivan Science Bu…, 301 McIver Street, Greensboro, North Carolina 27412, United States.
Jennifer H. Simpson
Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27402, United States
Hongzhou Wang
Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27402, United States
Bakhos A. Tannous
Experimental Therapeutics and Molecular Imaging Laboratory, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Boston, MA 02129, United States; Neuroscience Program, Harvard Medical School, Boston MA 02129, United States
Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers.Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA duplexes focused on selected individual epitranscriptomic variation. There are also limited development on the computational modeling of RNA duplexes containing a specific epitranscriptomic variation.This study aims to theoretically estimate the physical properties of different modified ribonucleosides and compare their variations with respect to altering the molecular structure of an RNA duplex.
