A Comprehensive Review of the Pharmacological Properties and Bioactive Components of <i>Retama monosperma</i>
Adil El Yadini,
Youssef Elouafy,
Ehsan Amiri-Ardekani,
Mina Shafiee,
Amirhosein Firouzi,
Najmeh Sasani,
Asaad Khalid,
Ashraf N. Abdalla,
Saad Bakrim,
Ching Siang Tan,
Khang Wen Goh,
Long Chiau Ming,
Abdelhakim Bouyahya
Affiliations
Adil El Yadini
Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco
Youssef Elouafy
Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco
Ehsan Amiri-Ardekani
Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran
Mina Shafiee
Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran
Amirhosein Firouzi
Essential Oils Research Institute, University of Kashan, Kashan P.O. Box 87516-51998, Iran
Najmeh Sasani
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz P.O. Box 64685-71468, Iran
Asaad Khalid
Substance Abuse and Toxicology Research Center, Jazan University, Jazan 45142, Saudi Arabia
Ashraf N. Abdalla
Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia
Saad Bakrim
Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnologies, and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir 80000, Morocco
Ching Siang Tan
School of Pharmacy, KPJ Healthcare University College, Nilai 71800, Malaysia
Khang Wen Goh
Faculty of Data Science and Information Technology, INTI International University, Nilai 71800, Malaysia
Long Chiau Ming
School of Medical and Life Sciences, Sunway University, Sunway City 47500, Malaysia
Abdelhakim Bouyahya
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco
Retama monosperma L. (Boiss.) or Genista monosperma L. (Lam.), known locally as “R’tam”, is a spontaneous and annual herb that belongs to the Fabaceae family. It is native to the Mediterranean regions, specifically in the desert areas and across the Middle Atlas in Morocco. This plant has been extensively used in folk medicine and it is rich in bioactive compounds, including polyphenols, flavonoids, and alkaloids. Current research efforts are focusing on the development of novel natural drugs as alternatives to various organic and non-organic chemical products from Retama monosperma. In addition, extract, and isolated compounds obtained from different parts of the chosen plant have been described to exhibit multiple biological and pharmacological properties such as antioxidant, anti-aging, anti-inflammatory, antihypertensive, anti-helminthic, disinfectant, diuretic, and hypoglycemic effects. The plant-derived extract also acts as an antimicrobial agent, which is highly efficient in the treatment of bacterial, viral, and fungal infections. Its antiproliferative effects are associated with some mechanisms, such as the inhibition of cell cycle arrest and apoptosis. In light of these assessments, we critically highlight the beneficial effects of the flowers, stems, seeds extracts, and isolated compounds from R. monosperma (L.) Boiss in human health care, industrial, and other applications, as well as the possible ways to be employed as a potential natural source for future drug discovery.